Numerous residential access technologies face path MTU discovery issues. PPPoE connections (with MTU = 1492 bytes instead of 1500 bytes) is the best-known example, and we’ll see more of them as various tunneling-based IPv4-to-IPv6 transition mechanisms (6rd, DS-Lite, MAP-E) become more popular.
Obviously you could use the same old MSS clamping tricks in the brave new IPv6 world or decide (like DS-Lite) to deal with IP fragmentation in underlay access networks ... but there’s another option in the IPv6 world: reduce client-side MTU with router advertisement messages.
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