Does dedicated iSCSI infrastructure make sense?

Chris Marget recently asked a really interesting question:

I've encountered an environment where the iSCSI networks are built just like FC networks: Multipathing software in use on servers and storage, switches dedicated to "SAN A" and "SAN B" VLANs, and full isolation of paths (redundant paths) between server and storage. I understand creating a dedicated iSCSI VLAN, but why would you need two? Isn’t the whole thing running on top of TCP? Am I missing something?

Well, it actually makes sense in some mission-critical environments.

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