When I wrote the Virtual switches need BPDU guard blog post, I speculated that you could shut down a whole HA cluster with a single BPDU-generating VM ... and got a nice confirmation during the Troopers 13 conference – ERNW specialists successfully demonstrated the attack while testing the security aspects of a public cloud implementation for a major service provider.
For more information, read their blog post (they also have a nice presentation explaining how a VM can read ESXi hard drive with properly constructed VMDK file).
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